Decreased expression of ubiquilin-1 following neonatal hypoxia-ischemic brain injury in mice
Identifieur interne : 000904 ( Main/Exploration ); précédent : 000903; suivant : 000905Decreased expression of ubiquilin-1 following neonatal hypoxia-ischemic brain injury in mice
Auteurs : Li Luo [République populaire de Chine] ; Yilin Liu [République populaire de Chine] ; Xing Tu [République populaire de Chine] ; Xuxin Ren [République populaire de Chine] ; Wenyan Zhao [République populaire de Chine] ; Jing Liu [République populaire de Chine] ; Li Zhang [République populaire de Chine] ; Weiqiang Chen [République populaire de Chine] ; Pei Zhang [République populaire de Chine] ; Weicai Wang [République populaire de Chine] ; Lanhai Lü [République populaire de Chine, États-Unis] ; Mengxia Wang [République populaire de Chine]Source :
- Molecular Medicine Reports [ 1791-2997 ] ; 2019.
Abstract
Ubiquilin-1 (Ubqln), a ubiquitin-like protein, regulates degradation of misfolded proteins and has been reported to have a crucial role in multiple pathologic and physiologic conditions. The current study was undertaken to investigate the expression of Ubqln in the brain of a neonatal hypoxia-ischemic (HI) brain injury model induced using the Rice method with some modifications. Mouse pups at postnatal day 7 day were used in this study. Pups underwent permanent ligation of the left common carotid artery and a consecutive hypoxic challenge (8% O2 and 92% N2 for 120 min). The expression of Ubqln in the brain of pups following HI was analyzed by immunofluorescence staining and western blot analysis. Immunofluorescence staining demonstrated that Ubqln was extensively distributed in the cerebral cortex and hippocampus, and Ubqln was expressed in neurons, astrocytes and microglia in the brains of the HI brain injury model mice. Western blot analyses revealed decreased expression of Ubqln in the HI penumbra of the mouse model compared with Ubqln in the sham control group. The results of this study revealed that HI alters the expression of Ubqln, thus may provide a novel understanding of role of Ubqln in neonatal hypoxic ischemic encephalopathy.
Url:
DOI: 10.3892/mmr.2019.10168
PubMed: 31059032
PubMed Central: 6522830
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Pei" sort="Zhang, Pei" uniqKey="Zhang P" first="Pei" last="Zhang">Pei Zhang</name><affiliation wicri:level="1"><nlm:aff id="af3-mmr-19-06-4597">Department of Obstetrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630</wicri:regionArea><wicri:noRegion>Guangdong 510630</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Weicai" sort="Wang, Weicai" uniqKey="Wang W" first="Weicai" last="Wang">Weicai Wang</name><affiliation wicri:level="1"><nlm:aff id="af4-mmr-19-06-4597">Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055</wicri:regionArea><wicri:noRegion>510055</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Lanhai" sort="Lu, Lanhai" uniqKey="Lu L" first="Lanhai" last="Lü">Lanhai Lü</name><affiliation wicri:level="1"><nlm:aff id="af4-mmr-19-06-4597">Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055</wicri:regionArea><wicri:noRegion>510055</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-mmr-19-06-4597">Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202</wicri:regionArea><wicri:noRegion>KY 40202</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Mengxia" sort="Wang, Mengxia" uniqKey="Wang M" first="Mengxia" last="Wang">Mengxia Wang</name><affiliation wicri:level="1"><nlm:aff id="af6-mmr-19-06-4597">Intensive Care Unit, Guangdong No. 2 Provincial People's Hospital, Guangzhou, Guangdong 510317, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Intensive Care Unit, Guangdong No. 2 Provincial People's Hospital, Guangzhou, Guangdong 510317</wicri:regionArea><wicri:noRegion>Guangdong 510317</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31059032</idno><idno type="pmc">6522830</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522830</idno><idno type="RBID">PMC:6522830</idno><idno type="doi">10.3892/mmr.2019.10168</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000705</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000705</idno><idno type="wicri:Area/Pmc/Curation">000705</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000705</idno><idno type="wicri:Area/Pmc/Checkpoint">000843</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000843</idno><idno type="wicri:Area/Ncbi/Merge">000594</idno><idno type="wicri:Area/Ncbi/Curation">000594</idno><idno type="wicri:Area/Ncbi/Checkpoint">000594</idno><idno type="wicri:doubleKey">1791-2997:2019:Luo L:decreased:expression:of</idno><idno type="wicri:Area/Main/Merge">000904</idno><idno type="wicri:Area/Main/Curation">000904</idno><idno type="wicri:Area/Main/Exploration">000904</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Decreased expression of ubiquilin-1 following neonatal hypoxia-ischemic brain injury in mice</title><author><name sortKey="Luo, Li" sort="Luo, Li" uniqKey="Luo L" first="Li" last="Luo">Li Luo</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-19-06-4597">School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yilin" sort="Liu, Yilin" uniqKey="Liu Y" first="Yilin" last="Liu">Yilin Liu</name><affiliation wicri:level="1"><nlm:aff id="af2-mmr-19-06-4597">School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Tu, Xing" sort="Tu, Xing" uniqKey="Tu X" first="Xing" last="Tu">Xing Tu</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-19-06-4597">School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Xuxin" sort="Ren, Xuxin" uniqKey="Ren X" first="Xuxin" last="Ren">Xuxin Ren</name><affiliation wicri:level="1"><nlm:aff id="af2-mmr-19-06-4597">School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Wenyan" sort="Zhao, Wenyan" uniqKey="Zhao W" first="Wenyan" last="Zhao">Wenyan Zhao</name><affiliation wicri:level="1"><nlm:aff id="af2-mmr-19-06-4597">School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-19-06-4597">School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-19-06-4597">School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Weiqiang" sort="Chen, Weiqiang" uniqKey="Chen W" first="Weiqiang" last="Chen">Weiqiang Chen</name><affiliation wicri:level="1"><nlm:aff id="af1-mmr-19-06-4597">School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006</wicri:regionArea><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Pei" sort="Zhang, Pei" uniqKey="Zhang P" first="Pei" last="Zhang">Pei Zhang</name><affiliation wicri:level="1"><nlm:aff id="af3-mmr-19-06-4597">Department of Obstetrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630</wicri:regionArea><wicri:noRegion>Guangdong 510630</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Weicai" sort="Wang, Weicai" uniqKey="Wang W" first="Weicai" last="Wang">Weicai Wang</name><affiliation wicri:level="1"><nlm:aff id="af4-mmr-19-06-4597">Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055</wicri:regionArea><wicri:noRegion>510055</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Lanhai" sort="Lu, Lanhai" uniqKey="Lu L" first="Lanhai" last="Lü">Lanhai Lü</name><affiliation wicri:level="1"><nlm:aff id="af4-mmr-19-06-4597">Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology and Institute of Stomatological Research, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, 510055</wicri:regionArea><wicri:noRegion>510055</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af5-mmr-19-06-4597">Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202</wicri:regionArea><wicri:noRegion>KY 40202</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Mengxia" sort="Wang, Mengxia" uniqKey="Wang M" first="Mengxia" last="Wang">Mengxia Wang</name><affiliation wicri:level="1"><nlm:aff id="af6-mmr-19-06-4597">Intensive Care Unit, Guangdong No. 2 Provincial People's Hospital, Guangzhou, Guangdong 510317, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Intensive Care Unit, Guangdong No. 2 Provincial People's Hospital, Guangzhou, Guangdong 510317</wicri:regionArea><wicri:noRegion>Guangdong 510317</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Medicine Reports</title><idno type="ISSN">1791-2997</idno><idno type="eISSN">1791-3004</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Ubiquilin-1 (Ubqln), a ubiquitin-like protein, regulates degradation of misfolded proteins and has been reported to have a crucial role in multiple pathologic and physiologic conditions. The current study was undertaken to investigate the expression of Ubqln in the brain of a neonatal hypoxia-ischemic (HI) brain injury model induced using the Rice method with some modifications. Mouse pups at postnatal day 7 day were used in this study. Pups underwent permanent ligation of the left common carotid artery and a consecutive hypoxic challenge (8% O<sub>2</sub> and 92% N<sub>2</sub> for 120 min). The expression of Ubqln in the brain of pups following HI was analyzed by immunofluorescence staining and western blot analysis. Immunofluorescence staining demonstrated that Ubqln was extensively distributed in the cerebral cortex and hippocampus, and Ubqln was expressed in neurons, astrocytes and microglia in the brains of the HI brain injury model mice. Western blot analyses revealed decreased expression of Ubqln in the HI penumbra of the mouse model compared with Ubqln in the sham control group. The results of this study revealed that HI alters the expression of Ubqln, thus may provide a novel understanding of role of Ubqln in neonatal hypoxic ischemic encephalopathy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lv, H" uniqKey="Lv H">H Lv</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Wu, S" uniqKey="Wu S">S Wu</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Ren, P" uniqKey="Ren P">P Ren</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silveira, Rc" uniqKey="Silveira R">RC Silveira</name></author><author><name sortKey="Procianoy, Rs" uniqKey="Procianoy R">RS 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uniqKey="Chen W" first="Weiqiang" last="Chen">Weiqiang Chen</name><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><name sortKey="Liu, Yilin" sort="Liu, Yilin" uniqKey="Liu Y" first="Yilin" last="Liu">Yilin Liu</name><name sortKey="Lu, Lanhai" sort="Lu, Lanhai" uniqKey="Lu L" first="Lanhai" last="Lü">Lanhai Lü</name><name sortKey="Ren, Xuxin" sort="Ren, Xuxin" uniqKey="Ren X" first="Xuxin" last="Ren">Xuxin Ren</name><name sortKey="Tu, Xing" sort="Tu, Xing" uniqKey="Tu X" first="Xing" last="Tu">Xing Tu</name><name sortKey="Wang, Mengxia" sort="Wang, Mengxia" uniqKey="Wang M" first="Mengxia" last="Wang">Mengxia Wang</name><name sortKey="Wang, Weicai" sort="Wang, Weicai" uniqKey="Wang W" first="Weicai" last="Wang">Weicai Wang</name><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><name sortKey="Zhang, Pei" sort="Zhang, Pei" uniqKey="Zhang P" first="Pei" last="Zhang">Pei Zhang</name><name sortKey="Zhao, Wenyan" sort="Zhao, Wenyan" uniqKey="Zhao W" first="Wenyan" last="Zhao">Wenyan Zhao</name></country><country name="États-Unis"><noRegion><name sortKey="Lu, Lanhai" sort="Lu, Lanhai" uniqKey="Lu L" first="Lanhai" last="Lü">Lanhai Lü</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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